1983 M.D. in surgery (with Distinction), Lviv Medical University, Lviv, Ukraine.
1987 Ph.D. in Biochemistry, Kavetsky Institute of Oncology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.


Research interests:

Regulation of cell growth and metabolism in normal and cancer cells, in particular

• cell growth, metabolism and proliferation via the mTOR/S6K pathway;
• the role of Coenzyme A and its derivatives in cellular metabolism and gene expression

Development of novel diagnostic and therapeutic approaches for cancer


Honors and awards:

International Agency for Research on Cancer, Fellowship 1988-1989
Amgen Research Fellowship, 1991-1993
Visiting Professorship, Biosignal Research Center, Kobe University, 1997-1998
SCE MBA Elective, London Business School, UK, 2001
Professor of Cancer Biochemistry, University College London, UK, 2002
Honorary Professor, Lviv National Medical University, Ukraine, 2003
Honorary Medal for the Promotion of Science in Ukraine, 2004


Professional membership:

Member of the Council of Sciences, INTAS (2004-2007)
Ukrainian Biochemical Society (Member)
Biochemical Society, UK (Member)
Member of the MRC College of Experts, UK
Society for Cell Sciences, UK (Member)


Selected publications:

1. Goh ET, Pardo OE, Michael N, Niewiarowski A, Totty N, Volkova D, Tsaneva IR, Seckl MJ, Gout I. Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway. J Biol Chem. 2010 May 28;285(22):17065-76.
2. Fenton TR, Gwalter J, Ericsson J, Gout IT. Histone acetyltransferases interact with and acetylate p70 ribosomal S6 kinases in vitro and in vivo. Int J Biochem Cell Biol. 2010 Feb;42(2):359-66.
3. Gwalter J, Wang ML, Gout I. The ubiquitination of ribosomal S6 kinases is independent from the mitogen-induced phosphorylation/activation of the kinase. Int J Biochem Cell Biol. 2009 Apr;41(4):828-33.
4. Wang ML, Panasyuk G, Gwalter J, Nemazanyy I, Fenton T, Filonenko V, Gout I. Regulation of ribosomal protein S6 kinases by ubiquitination. Biochem Biophys Res Commun. 2008 May 2;369(2):382-7.
5. Panasyuk G, Nemazanyy I, Zhyvoloup A, Bretner M, Litchfield DW, Filonenko V, Gout IT. Nuclear export of S6K1 II is regulated by protein kinase CK2 phosphorylation at ser 17. J Biol Chem., Aug 8; PMID: 16895915, 2006.
6. Rebholz H, Panasyuk G, Fenton T, Nemazanyy I, Valovka T, Flajolet M, Ronnstrand L, Stephens L, West A, Gout IT. Receptor association and tyrosine phosphorylation of S6 kinases. FEBS J. 2006 May;273(9):2023-36.
7. Nemazanyy I, Panasyuk G, Breus O, Zhyvoloup A, Filonenko V, Gout IT. Identification of a novel CoA synthase isoform, which is primarily expressed in the brain. Biochem Biophys Res Commun. 2006 Mar 24;341(4):995-1000. Epub 2006 Jan 24.
8. Zhyvoloup A, Nemazanyy I, Panasyuk G, Valovka T, Fenton T, Rebholz H, Wang ML, Foxon R, Lyzogubov V, Usenko V, Kyyamova R, Gorbenko O, Matsuka G, Filonenko V, Gout IT. Subcellular localization and regulation of coenzyme A synthase. J Biol Chem. 2003 Dec 12;278(50):50316-21.
9. Valovka T, Verdier F, Cramer R, Zhyvoloup A, Fenton T, Rebholz H, Wang ML, Gzhegotsky M, Lutsyk A, Matsuka G, Filonenko V, Wang L, Proud CG, Parker PJ, Gout IT. Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization. Mol Cell Biol. 2003 Feb;23(3):852-63.
10. Zhyvoloup A, Nemazanyy I, Babich A, Panasyuk G, Pobigailo N, Vudmaska M, Naidenov V, Kukharenko O, Palchevskii S, Savinska L, Ovcharenko G, Verdier F, Valovka T, Fenton T, Rebholz H, Wang ML, Shepherd P, Matsuka G, Filonenko V, Gout IT. Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis. J Biol Chem. 2002 Jun 21;277(25):22107-10.