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Volodymyr Tryndyak
Position: Staff fellow of the Division of Biochemical Toxicology at the National Center for Toxicological Research. Address: 3900 NCTR Rd, HFT-140, Jefferson, AR 72079 USA Phone: 011-870-543-7545 Fax: 011-870-543-7610 Home page: go to >> E-mail: volodymyr.tryndyak<AT>fda.hhs.gov |
1998 M.Sc. in Biochemistry, Ivan Franko National University of Lviv, Lviv, Ukraine.
2004 Ph.D. in Oncology, R.E.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine.
Scientific interests:
- Genetics and epigenetics of cancer
- Multidrug resistance in cancer
Honors and awards:
2001 Presidential Scholarship Award for Young Scientists, Kyiv, Ukraine.
2004 Post-doctoral Fellowship, Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
Professional membership:
American Association for Cancer Research (Associate member)
Society of Toxicology (Fellow)
Selected publications:
- Tryndyak V.P., Han T., Muskhelishvili L., Fuscoe J.C., Ross S.A., Beland F.A., Pogribny I.P. Coupling global methylation and gene expression profiles reveals key pathophysiological events in liver injury induced by a methyl-deficient diet. Molecular Nutrition and Food Research. 2010; (in press).
- Starlard-Davenport A., Tryndyak V.P., Kosyk O., Ross S.A., Rusyn I., Beland F.A., Pogribny I.P Dietry methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis. World Rev Nutr Diet. 2010; 101: 123-130.
- Tryndyak V.P., Beland F.A., Pogribny I.P. E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. Int. J. Cancer. 2010; 126(11): 2575-2583.
- Pogribny I.P., Tryndyak V.P., Bagnyukova T.V., Melnyk S., Montgomery B., Ross S.A., Latendresse J.R., Rusyn I., Beland F.A. Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet. J. Hepatol. 2009; 51(1): 176-186.
- Pogribny I.P., Muskhelishvili L., Tyryndyak V.P., Beland F.A. The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation. Molecular Toxicology and Applied Pharmacology. 2009; 235(3): 305-311.
- Tyryndyak V.P., Ross S.A., Beland F.A., Pogribny I.P. Down-regulation of the microRNAs miR-34a, miR-127 and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Molecular Carcinogenesis. 2009; 48(6): 479-487.
- Pogribny I.P., Karpf A.R., James S.R., Melnyk S., Han T., Tryndyak V.P. Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet. Brain Res. 2008; 1237: 25-34.
- Kovalchuk O., Tryndyak V.P., Montgomery B., Boyko A., Kutanzi K., Zemp F., Warbitton A.R., Lafendresse J.R., Kovalchuk I., Beland F.A., Pogribny I.P. Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications, and aberrant microRNA expression. Cell Cycle. 2007; 6(16): 2010-2018.
- Pogribny I.P., Bagnyukova T.V., Tryndyak V.P., Muskhelishvili L., Rodriguez-Juarez R., Kovalchuk O., Han T., Fuscoe J.C., Ross S.A., Beland F.A. Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis. Toxicology and Applied Pharmacology. 2007; 225(1): 61-9.
- Pogribny I.P., Tryndyak V.P., Woods C.G., Witt S.E., Rusyn I. Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha. Mutation Research. 2007; 625(1-2): 62-71.
- Pogribny I.P., Tryndyak V.P., Boyko A., Rodriguez-Juarez R., Beland F.A., Kovalchuk O. Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure. Mutation Research. 2007; 619: 30-37.
- Chekhun V.F., Lukyanova N.Yu., Kovalchuk O., Tryndyak V.P., Pogribny I.P. Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets. Mol. Cancer Ther. 2007; 6(3): 1089-98.
- Tryndyak V.P., Kovalchuk O., Muskhelishvili L., Montgomery B., Rodriguez-Juarez R., Melnyk S., Ross S.A., Beland F.A., Pogribny I.P. Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis. Mol. Carcinogenesis. 2007; 46(3): 187-97.
- Tryndyak V.P., Kovalchuk O., Pogribny I.P. Identification of differentially methylated sites within unmethylated DNA domains in normal and cancer cells. Analyt. Biochem. 2006; 356(2): 202-207.
- Tryndyak V.P., Muskhelishvili L., Kovalchuk O., Rodriguez-Juarez R., Montgomery B., Churchwell M.I., Ross S.A., Beland F.A., Pogribny I.P. Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis. Carcinogenesis. 2006; 27(8): 1713-1720.
- Pogribny I.P., Ross S.A., Tryndyak V.P., Pogribna M., Poirier L.A., Karpinets T.V. Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. Carcinogenesis. 2006; 27(6): 1180-1186.
- Tryndyak V., Kovalchuk O., Pogribny I. Loss of DNA Methylation and Histone H4 Lysine 20 Trimethylation in Human Breast Cancer Cells is Associated with Aberrant Expression of DNA Methyltransferase 1, Suv4-20h2 Histone Methyltransferase and Methyl-Binding Proteins. Cancer Biol. Ther. 2006; 5(1): 65-70.
- Pogribny I.P., Ross S.A., Wise C., Pogribna M., Jones E.A., Tryndyak V.P., James S.J., Dragan Y.P., Poirier L.A. Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency. Mutation Research. 2006; 593(1-2): 80-87.
- Chekhun V.F., Kulik G.I., Yurchenko O.V., Tryndyak V.P., Todor I.N., Luniv L.S., Tregubova N.A., Pryzimirska T.V., Montgomery B., Rusetskaya N.V., Pogribny I.P. Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells. Cancer Letters. 2006; 231(1): 87-93.
- Pogribny I., Koturbash I., Tryndyak V., Hudson D., Stevenson S.M.L., Sedelnikova O., Bonner W., Kovalchuk O. Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus. Mol. Cancer Res. 2005; 3(10): 553-561.
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