Vladimir Kashuba Position: Principal investigator in the Department of Microbiology, Tumor and Cell Biology of Karolinska Institute, Stockholm, Sweden. Head of the Molecular Oncogenetics Laboratory, Institute of Molecular Biology and Genetics, NASU, Kyiv, Ukraine. Address: Box 280, Stockholm, S-171 77, Sweden Phone: +46 8 52 48 67 37 Fax: +46 8 31 94 70 E-mail: vlakas<AT>ki.se

1990 Ph.D. in Molecular Biology, Institute of Molecular Biology and Genetics, NASU, Kyiv, Ukraine.
2009 Doctor of Science (habilitation) in Molecular Biology, Institute of Molecular Biology and Genetics, NASU, Kyiv, Ukraine.


Scientific interests:

• molecular biology
• cancer
• tumor suppressor genes
• epigenetics

Professional membership:

European Association of Cancer Research (Member)

Selected publications:

1. Gerashchenko GV, Bogatyrova OO, Rudenko EE, Kondratov AG, Gordiyuk VV, Zgonnyk YM, Vozianov OF, Pavlova TV, Zabarovsky ER, Rynditch AV, Kashuba VI. Genetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas. Exp Oncol. 2010 Jul;32(2):71-5.

2. Senchenko VN, Anedchenko EA, Kondratieva TT, Krasnov GS, Dmitriev AA, Zabarovska VI, Pavlova TV, Kashuba VI, Lerman MI, Zabarovsky ER. Simultaneous down-regulation of tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer. BMC Cancer. 2010;10(1):75.

3. Elena Kashuba, Surya Pavan Yenamandra, Suhas Deoram Darekar, Mariya Yurchenko, Vladimir Kashuba, George Klein and Laszlo Szekely. MRPS18-2 protein immortalizes primary rat embryonic fibroblasts and endows them with stem cell like properties. Proc. Natl. Acad. Sci. USA, 2009, 106(47):19866-19871.

4. Kashuba VI, Pavlova TV, Grigorieva EV, Kutsenko A, Yenamandra SP, Li J, Wang F, Protopopov AI, Zabarovska VI, Senchenko V, Haraldson K, Eshchenko T, Kobliakova J, Vorontsova O, Kuzmin I, Braga E, Blinov VM, Kisselev LL, Zeng YX, Ernberg I, Lerman MI, Klein G, Zabarovsky ER. High mutability of the tumour suppressor genes RASSF1 and RBSP3 in cancer. PLoS ONE. 2009, 4(5): e5231.

5. T. V. Pavlova, V. I. Kashuba, O. V. Muravenko, P. S. Yenamandra, T. A. Ivanova, V. I. Zabarovska, E. R. Rakhmanaliev, L. A. Petrenko, I. V. Pronina, V. I. Loginiv, O. Y. Yurkevich, L. L. Kisselev, A. V. Zelenin, E. R. Zabarovsky. Technology of analysis of epigenetic and structural changes of epithelial tumors genome with NotI-microarrays by the example of human chromosome3. Mol. Biol. 2009, 43(2): 339-347.

6. Fuli Wang, Jingfeng Li, Elvira V. Grigorieva, Vera N. Senchenko, Tatiana Pavlova, Ekaterina A. Anedchenko, Anna V. Kudryavtseva, Alexander Tsimanis, Michael I. Lerman, Vladimir I. Kashuba, George Klein and Eugene R. Zabarovsky. HYAL1 and HYAL2 are tumor suppressor genes with asymmetric suppressor effect in vitro and in vivo. PLoS ONE. 2008, 3(8): e3031.

7. V. I. Kashuba, I. Ya. Skrypkina, D. V. Saraev, V. V. Gordiyuk, A. B. Vinnytska, L. O. Tsyba, P. V. Pogrebnoy, V. M. Blinov, E. R. Zabarovsky, A. V. Rynditch: Identification of copy number and methylation changes in gene loci potentially associated with cervical cancer using NotI microarrays. Ukr. Biochem. Journ., 2006, v. 78, No 2, p. 49-56.

8. Vladimir I. Kashuba, Jingfeng Li, Fuli Wang, Vera N. Senchenko, Alexey Protopopov, Alena Malyukova, Alexey S. Kutsenko, Elena Kadyrova, Veronika I. Zabarovska, Olga V. Muravenko, Alexander V. Zelenin, Lev L. Kisselev, Igor Kuzmin, John D. Minna, Gösta Winberg, Ingemar Ernberg, Eleonora Braga, Michael I. Lerman, George Klein, Eugene R. Zabarovsky. RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies. Proc. Natl. Acad. Sci. USA, 2004, 101(14):4906-4911.

9. Kashuba VI, Braga EA, Maliukova AV, Loginov VI, Senchenko VN, Bazov IV, Kiselev LL, Zabarovskii ER: New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification. Mol. Biol. (Moscow-NY) 2003, 37: 170-185.

10. Kashuba V.I., Protopopov A., Zabarovska V.I., Muravenko O.V., Lerman M., Klein G. and Zabarovsky E.R. An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies. Cancer Res. 2003, 63: 404-412.