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Ihor Lemischka
Position: Director of the Black Family Stem Cell Institute; Lillian and Henry M. Stratton Professor of Gene and Cell Medicine and Professor of Developmental and Regenerative Biology, Mount Sinai Medical Center. Address: Department of Gene and Cell Medicine Mount Sinai School of Medicine Box 1496, One Gustave L. Levy Place New York, NY 10029 Phone: +1 212 659 8228 Fax: +1 212 803 6740 Home page: go to >> E-mail: ihor.lemischka<AT>mssm.edu |
1983 Ph.D. in biology, Massachusetts Institute of Technology.
Research interests:
Selected publications:
Research interests:
- molecular and cellular nature of the undifferentiated stem cell "states"
- changes of such states during a change in cell fate
Selected publications:
- Xonia Carvajal-Vergara, Ana Sevilla, Sunita L. D'Souza, Yen-Sin Ang, Christoph Schaniel, Dung-Fang Lee, Lei Yang, Aaron D. Kaplan, Eric D. Adler, Roye Rozov, YongChao Ge, Ninette Cohen, Lisa J. Edelmann, Betty Chang, Avinash Waghray, Jie Su, Sherly Pardo, Klaske D. Lichtenbelt, Marco Tartaglia, Bruce Gelb, Ihor R. Lemischka. Patient-specific induced pluripotent stem cell derived models of LEOPARD syndrome. Nature (In Press).
- Tarleton HP, Lemischka IR. Delayed differentiation in embryonic stem cells and mesodermal progenitors in the absence of CtBP2. Mech Dev 2010; 127(1-2): 107-19.
- Schaniel C, Ang YS, Ratnakumar K, Cormier C, James T, Bernstein E, Lemischka IR, Paddison PJ. Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells. Stem Cells 2009; 27(12): 2979-91.
- Rong Lu, Florian Markowetz, Richard D. Unwin, Jeffrey T. Leek, Edoardo M. Airoldi, Ben D. MacArthur, Alexander Lachmann, Roye Rozov, Avi Ma'ayan, Laurie A. Boyer, Olga G. Troyanskaya, Anthony D. Whetton, Ihor R. Lemischka. Systems-level dynamic analyses of fate change in murine embryonic stem cells. Nature 2009; 462: 358-362.
- Fasano C, Dimos JT, Ivanova NB, Lowry N, Lemischka IR, Temple S. shRNA knockdown of Bmi-1 reveals a critical role for p21/Rb pathway in NSC self-renewal during development. Cell Stem Cell 2007; 1: 87-99.
- Ivanova N, Dobrin R, Lu R, Kotenko I, Levorse J, DeCoste C, Schafer X, Lun Y, Lemischka IR. Dissecting self-renewal in stem cells with RNA interference. Nature 2006; 442: 533-538.
- Moore KA, Lemischka IR. Stem cells and their niches. Science 2006; 311: 1880-1885.
- Schaniel C, Li F, Schafer X, Moore T, Lemischka I, Paddison P. Delivery of short hairpin RNAs-triggers of gene silencing into mouse embryonic stem cells. Nature Methods 2006; 3: 6946-6951.
- Pritsker M, Ford N, Jenq H, Lemischka IR. Genome-wide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells. Proc. Natl, Acad Sci USA 2006; 103: 6946-6951.
- Shen Q, Wang Y, Dimos JT, Fasano CA, Phoenix TN, Lemischka IR, Ivanova NB, Stifani S, Morrisey EE, Temple S. The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nat Neurosci. 2006; 9: 743-751.
- Pritsker M, Doniger T, Kramer L, Westcot S, Lemischka IR. Diversification of stem cell molecular repertoire by alternative splicing. Proc. Natl. Acad. Sci. USA 2005; 102: 14290-14295.
- Ivanova NB, Dimos JT, Schaniel C, Hackney JA, Moore KA, Lemischka IR. A stem cell molecular signature. Science 2002; 298: 601-604.
- Phillips RL, Ernst RE, Brunk B, Ivanova N, Mahan MA, Deanehan JK, Moore KA, Overton GC, Lemischka IR. The Genetic Program of Hematopoietic Stem Cells. Science 2000; 288: 1635-1640.
- Petrenko O, Beavis A, Klaine M, Godin I, Lemischka IR. The molecular characterization of the fetal stem cell marker AA4. Immunity 1999; 10: 691-700.
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