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Ivan Rusyn
Position: M.D., Ph.D., Professor of the Environmental Sciences and Engineering Department in University of North Carolina. Address: 0031 MHRC, CB#7431, Chapel Hill, NC, 27599, USA Phone: 8-10-1-919-843-2596 Home page: go to >> E-mail: iir<AT>unc.edu |
1994 M.D., Ukrainian State Medical University, Kyiv, Ukraine (with Honors).
2000 Ph.D. in Toxicology, University of North Carolina at Chapel Hill.
Scientific interests:
- Toxicology
- Environmental Health
Honors and awards:
2008 Achievement Award, Society of Toxicology
2002-2005 Transition to Independent Position Award, NIEHS
2000-2002 Individual Postdoctoral National Research Service Award, NIEHS
2000-2001 Leon & Bertha Golberg Memorial Postdoctoral Fellowship, UNC-Chapel Hill
2000 Visiting Professor of Surgery, Yamanashi Medical University, Japan
2000 Young Investigator Award, Soc. for Free Radical Research International
2000 AACR - Bristol Myers Squibb Oncology Young Investigator Scholar Award
2000 Carl C. Smith Mechanisms Specialty Section Award, Society of Toxicology
1998/99/2001 Young Investigator Award, Oxygen Society
1995-1996 Research Fellowship, German Academic Exchange Service (DAAD)
1994 First Class Honors Diploma, Ukrainian State Medical University, Kiev, Ukraine
Professional membership:
Society of Toxicology
Selected publications (from 99 total):
- Formeister, E.J., Tsuchiya, M., Fujii, H., Shpyleva, S., Pogribny, I., and Rusyn, I. Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma. Mutat Res: vol.692, p.26-33, 2010.
- Gatti, D.M., Zhao, N., Chesler, E.J., Bradford, B.U., Shabalin, A., Yordanova, R., Lu, L., and Rusyn, I. Sex-specific gene expression in BXD mouse liver. Physiol Genomics: vol.42, p.456-468, 2010.
- Rusyn. I., Gatti, D.M., Wiltshire, T., Kleeberger, S.R., and Threadgill, D.W. Toxicogenetics: population-based testing of drug and chemical safety in mouse models. Pharmacogenomics: vol.11, p.1127-1136, 2010.
- Rusyn. I., and Daston, G.P. Computational Toxicology: Realizing the Promise of the Toxicity Testing in the 21st Century. Environ Health Perspect: vol.118, p.1047-1050, 2010.
- Tsuchiya, M., Parker, J., Kono, H., Matsuda, M., Fujii, H., and Rusyn, I. Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma. Mol Cancer: vol.9, p.74, 2010.
- Pogribny, I.P., Rusyn, I. and Beland, F.A. Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: Studies in rodents. Environ Mol Mutagen 49(1):9-15, 2008.
- Rusyn, I., Fry, R.C., Begley, T.J., Klapacz, J., Svensson, J.P., Ambrose, M., and Samson, L.D. Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates. PLoS ONE 2:e1252, 2007.
- Pogribny, I.P., Tryndyak, V.P., Woods, C.G., Witt, S.E., and Rusyn, I. Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor α. Mutat Res 625:62-71, 2007.
- Woods, C.G., Kosyk, O., Bradford, B.U., Ross, P.K., Burns, A.M., Cunningham, M.L., Qu, P., Ibrahim, J.G. and Rusyn I. Gene expression in mouse liver reveals a temporal shift in molecular pathways that mediate effects of peroxisome proliferators. Toxicol Appl Pharmacol 225:267-277, 2007.
- Peffer, R., Moggs, J.G., Pastoor, T., Currie, R.A., Wright, J., Millburn, G., Waechter, F., and Rusyn, I. Mouse liver effects of Cyproconazole, a triazole fungicide: Role of the constitutive androstane receptor. Toxicol Sci 99:315-325, 2007.
- Beyer, R., et al. Multi-center study of acetaminophen hepatotoxicity reveals the critical importance of biological endpoints in genomic analyses. Toxicol Sci 99:326-337, 2007.
- Roberts, A., McMillan, L., Wang, W., Parker, J., Rusyn, I., and Threadgill, D. Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows. Bioinformatics 23:i401-i407, 2007.
- Gatti, D., Maki, A., Chesler, E.J., Kirova, R., Lu, L., Wang, J., Williams, R.W., Perkins, A., Langston, M.A., Threadgill, D.W., and Rusyn, I. Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology 46:548-557, 2007.
- Woods, C.G., Burns, A.M., Bradford, B.U., Ross, P.K., Kosyk, O., Swenberg, J.A., Cunningham, M.L., and Rusyn I. WY-14,643-induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase. Toxicol Sci 98:366-74, 2007.
- Woods, C.G., Vanden Heuvel, J.P., and Rusyn, I. Genomic profiling in nuclear receptor-mediated toxicity. Toxicol Pathol 35:474-494, 2007.
- Hammond, L.E., Albright, C.D., He, L., Rusyn, I., Watkins, S.M., Doughman, S.D., Lemasters, J.J., and Coleman, R.A. Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice. Exp Mol Pathol 82:210-219, 2007.
- Maki, A., Kono, H., Gupta, M., Asakawa, M., Suzuki, T., Matsuda, M., Fujii, H., and Rusyn, I. Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma. Ann Surg Oncol 14:1182-90, 2007.
- Roberts, R.A., Ganey, P.E., Ju, C., Kamendulis, L.M., Rusyn, I., and Klaunig, J.E. Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicol Sci 96:2-15, 2007.
- Woods, C.G., Burns, A.M., Maki, A., Bradford, B.U., Cunningham, M.L., Connor, H.D., Kadiiska, M., Mason, R.P., Peters, J.M., and Rusyn, I. Sustained formation of α-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-α, but not NADPH oxidase. Free Radic Biol Med 42:335-342, 2007.
- Pogribny, I.P., Tryndyak, V.P., Muskhelishvili, L., Rusyn, I., and Ross, S.A. Methyl deficiency, alterations in global histone modifications and carcinogenesis. J Nutr 137:216S-222S, 2007. 16. Yamashina S, Ikejima K, Rusyn I, Sato N. Glycine as a potent anti-angiogenic nutrient for tumor growth. J Gastroenterol Hepatol. 22:S62-64, 2007.
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