Igor Pogribny Position: Laboratory Director, Principal Research Investigator, Division of Biochemical Toxicology, the National Center for Toxicological Research, Basic Science Professor, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences (Little Rock, AR). Address: 3900 NCTR Rd, Jefferson, 72079, USA Phone: 8-10-1-(870)-543-7096 Fax: 8-10-1-(870)-543-7136 E-mail: igor.pogribny<AT>fda.hhs.gov

1982 M.D., Medical University, Ivano-Frankivsk, Ukraine.
1986 Ph.D. in Biochemistry/Oncology, Medical University, Kyiv, Ukraine.

Scientific interests:

• epigenetics
• genetics
• the molecular biology of cancer
• molecular toxicology
• nutrition and cancer

Honors and awards:

FDA Outstanding Service Award

Professional membership:

American Association for Cancer Research
Environmental Mutagen Society
American Association for Advancement of Science

Member of editorial boards:

World Journal of Hepatology
Breast Cancer Journal
Experimental Oncology

Selected publications: 

1. Pogribny I.P., Starlard-Davenport A., Tryndyak V.P., Han T., Ross S.A., Rusyn I., Beland F.A. Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Laboratory Investigation, 2010, (in press).
2. Shpyleva S.I., Tryndyak V.P., Kovalchuk O., Starlard-Davenport A., Chekhun V.F., Beland F.A., Pogribny I.P. Role of ferritin alterations in human breast cancer cells. Breast Cancer Research and Treatment, 2010, (in press).
3. Pogribny I.P., Muskhelishvili L., Tryndyak V.P., Beland F.A. The role of epigenetic events in genotoxic hepatocarcinogenesis induced by 2-acetylaminofluore. Mutation Research, 2010, (in press).
4. Pogribny I.P., Filkowski J., Tryndyak V.P., Golubov A., Shpyleva S.I., Kovalchuk O. Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin. International Journal of Cancer, 2010, (in press).
5. Tryndyak V.P., Beland F.A., Pogribny I.P. E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. International Journal of Cancer, 2010, 126, 2575-2583.
6. Starlard-Davenport A., Tryndyak V.P., James S.R., Karpf A.R., Latendresse J.R., Beland F.A., Pogribny I.P. Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats. Carcinogenesis, 2010, 31: 376-381.
7. Pogribny I.P.,Tryndyak V.P., Bagnyukova T.V., Melnyk S., Montgomery B., Ross S.A., Latendresse J.R., Rusyn I., Beland F.A. Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet. Journal of Hepatology, 2009, 51: 176-186.
8. Tryndyak V.P., Ross S.A., Beland F.A., Pogribny I.P. Down-regulation of the microRNAs miR-34a, miR-127 and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Molecular Carcinogenesis, 2009, 48: 479-487.
9. Pogribny I.P., Beland F.A. DNA hypomethylation in the origin and pathogenesis of human diseases. Cellular and Molecular Life Sciences, 2009, 66: 2249-2261.
10. Pogribny I.P., Vanyushin B.F. Age-related genomic hypomethylation. In: Epigenetics of Aging, Tollefsbol T.O. (Ed.), Springer, 2009, pp. 11-27.
11. Pogribny I.P. MicroRNA dysregulation during chemical carcinogenesis. Epigenomics, 2009, 1: 281-290.
12. Carole Yauk, Aris Polyzos, Andrea Rowan-Carroll, Christopher M. Somers, Roger W. Godschalk, Frederik J. Van Schooten, M. Lynn Berndt, Igor P. Pogribny, Igor Koturbash, Andrew Williams, George R. Douglas, and Olga Kovalchuk. Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location. PNAS, 2008, 2: 605-610.
13. Pogribny I.P., Rusyn I., Beland F.A. Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: Studies in rodents. Environmental and Molecular Mutagenesis, 2008, 49(1): 9–15.
    
14. Pogribny I.P., Bagnyukova T.V., Tryndyak V.P., Muskhelishvili L., Rodriguez-Juarez R., Kovalchuk O., Han T., Fuscoe J.C., Ross S.A., Beland F.A. Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis. Toxicol. Appl. Pharmacol., 2007, 225: 61-69.
15. Kovalchuk O., Tryndyak V.P., Montgomery B., Boyko A., Kutanzi K., Zemp F., Warbritton A.R., Latendresse J.R., Kovalchuk I., Beland F.A., Pogribny I.P. Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression. Cell Cycle, 2007, 6: 2010-2018. 
16. Pogribny I.P., Tryndyak V.P., Boyko A., Rodriguez-Juarez R., Beland F.A., Kovalchuk O. Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure. Mutation Research, 2007, 619: 30-37.
17. Chekhun V.F., Lukyanova N.Yu., Kovalchuk O., Tryndyak V.P., Pogribny I.P. Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets. Mol. Cancer Therapeutics, 2007, 6, 1089-1098. 
18. Tryndyak V.P., Kovalchuk O., Muskhelishvili L., Montgomery B., Rodriguez-Juarez R., Melnyk S., Ross S.A., Beland F.A., Pogribny I.P. Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis. Mol. Carcinogenesis, 2007, 46: 187-197.
19. Kovalenko V.M., Bagnyukova T.V., Sergienko O.V., Bondarenko L.B., Shayakhmetova G.M., Matvienko A.V., Pogribny I.P. Epigenetic changes in the rat livers induced by pyrazinamide treatment. Toxicol. Appl. Pharmacol., 2007, 225: 293-299. 
20. Karpinets T.V., Greenwood G.J., Pogribny I.P. and N.F. Samatova. Bacterial Stationary-State Mutagenesis and Mammalian Tumorigenesis as Stress-Induced Cellular Adaptations and the Role of Epigenetics. Current Genomics, 2006, 7: 481-496.