Anna El’skaya Position: Director of the Institute of Molecular Biology and Genetics of NAS of Ukraine, Head of the Department of Translation Mechanisms of Genetic Information, Kyiv, Ukraine. Address: 150 Zabolotnogo St., Kyiv, 03680, Ukraine Phone: +38 044 526-1169 Fax: +38 044 526-0759 Home page: go to >> E-mail: elskaya<AT>imbg.org.ua

1976 Doctor of Science in molecular biology, Institute of Molecular Biology and Genetics, National Academy of Science, Kyiv, Ukraine.


Scientific interests:

• Mechanisms of protein synthesis and its regulation in high eukaryots.
• The elaboration of novel analytical systems, bio- and chemosensors, on the basis of different electrochemical transducers, biological objects, synthetic biomimics and molecular imprinted polymers.
  

Honors and awards:

1976 Academician A.V. Palladin Award (Ukraine)
1982 Diploma of the Presidium of Verkhovna Rada of Ukrainian SSR
1986 Ukrainian State Award in the field of science and technologies
1989 Diploma for a discovery (patent) by the State Committee on Matters of Discoveries and Inventions USSR
1998 Honoured Worker of Science and Technology of Ukraine
2004 Diploma of the Verhovna Rada of Ukraine
2005 Gold Medal of the Ukrainian Federation of Scientists
2006 Winner of the tenth national "Person of the Year" award in the "Academic of the Year" nomination
2008 Awarded the Order of Princess Olga, III degree
2009 "European Quality Award" and Europe Business Assembly diploma recipient
2010 Recipient of the "Professional Accomplishment Award" from the Ukrainian National Academy of Sciences


Professional membership:

Since 1991 – Ukrainian Biochemical Society (board member)
Since 1992 – National Academy of Science of Ukraine (full member)
Since 2003 – Ukrainian Biochemical Society (vice president)
Since 2003 – Academic Council of Institute of Molecular Biology and Genetics of NASU (head)
Since 2005 – Commission to Increase the Efficiency of the NASU (member)
Since 2007 – NASU's scientific and technical program "Sensor systems for environmental health and industrial and technological needs" (head)
Since 2010 – Scientific advisory group for the "Fundamentals of molecular and cellular biotechnology" program of NASU (head)


Member of editorial boards:

“Biopolymers and Cell” (Editor in Chief)
“Ukrainica Bioorganica Acta”
“Journal of the Ukrainian Society of Geneticists and Breeders”

Member of advisory boards:

“Ukrainian Biochemical Journal”
“Biotechnology”

Selected publications:

Protein biosynthesis

1. Veremieva M., Khoruzhenko A., Zaicev S., Negrutskii B., El’skaya A. Unbalanced expression of the translation complex eEF1 subunits in human cardioesophageal carcinoma. European Journal of Clinical Investigation. 21 October 2010, published on-line.

2. Tokovenko B., Golda R., Protas O., Obolenskaya M., El'skaya A. COTRASIF: conservation-aided transcription-factor-binding site finder. Nucleic Acids Res. 2009 Apr; 37(7): e 49.

3. Budkevich T., El'skaya A., Nierhaus K. Features of 80S mammalian ribosome and its subunits. Nucleic Acids Res. 2008 ; 36 (14): 4736-44.

4. Panasyuk G., Nemazanyy I., Filonenko V., Negrutskii B., El'skaya A. A2 isoform of mammalian translation factor eEF1A displays increased tyrosine phosphorylation and ability to interact with different signalling molecules Int J Biochem Cell Biol. 2008 ; 40 (1): 63-71.

5. Kanibolotsky D., Novosyl'na O., Abbott C., Negrutskii B., El'skaya A. Multiple molecular dynamics simulation of the isoforms of human translation elongation factor 1A reveals reversible fluctuations between "open" and "closed" conformations and suggests specific for eEF1A1 affinity for Ca2+-calmodulin. BMC Struct Biol. 2008; 8:4.

6. Lukash, T., Turkivska H., Negrutskii B., El'skaya A. Chaperone-like activity of mammalian elongation factor eEF1A: Renaturation of aminoacyl-tRNA synthetases. International Journal of Biochemistry & Cell Biology. -2004.- V.-36.- P. 1341-1347.

7. Budkevich T., Timchenko A., Tiktopulo E., Negrutskii B., Shalak V., Petrushenko Z., Aksenov V., Willumeit R., Kohlbrecher J., Serdyuk I., El'skaya A., Еxtended conformation of mammalian translation elongation factor 1A in solution, Biochemistry. -2003. - 24. -N51. -P.15342-15349.

8. Budkevich T., Timchenko A., Tiktopulo E., Negrutskii B., Shalak V., Petrushenko Z., Aksenov V., Willumeit R., Kohlbrecher J., Serdyuk I., El'skaya A. Extended conformation of mammalian translation elongation factor 1A in solution.Biochemistry. - 2002. - V. 41. - P. 15342-15349.

9. Petrushenko Z., Budkevich T., Shalak V., Negrutskii B., El'skaya A. Novel complexes of mammalian translation elongation factor eEF1A*GDP with uncharged tRNA and aminoacyl-tRNA synthetase. Implications for tRNA channeling. Eur. J. Biochem. - 2002. -V.269. - P. 4811-4818.

10. Turkovskaya H., Belyanskaya L., Kovalenko M., El'skaya A. Renaturation of rabbit liver aminoacyl-tRNA synthetases by 80S ribosomes. Int. J. Biochem. Cell Biol. - 1999. - V. 31. - P. 759-768.

11. Negrutskii B., Shalak V., Kerjan P., El'skaya A. Mirande M. Functional interaction of mammalian valyl-tRNA synthetase with elongation factor EF-1 in the complex with EF-1H. Journ.Biol. Chem. - 1999. - V. 274. - P. 4545-4550.

12. Negrutskii B., El'skaya A. Eukaryotic translation elongation factor 1. Structure, expression, function and possible role in aminoacyl-tRNA channeling // In: Progress in Nucleic Acid Research and Molecular Biology, eds K.Moldave et al., Academic Press, San Diego/ New York/ Boston/ London/ Sydney/ Tokyo/ Toronto. - 1998. - V. 60. - P. 7-78.

13. Petrushenko Z., Negrutskii B., Ladokhin A., Budkevich T., Shalak V., El'skaya A. Evidence for the formation of an unusual ternary complex of rabbit liver EF-1а with GDP and deacylated tRNA. -1997.- FEBS Lett. 407, 13-17.

14. Negrutskii B., Budkevich T., Shalak V., Turkovskaya G., El'skaya A. Rabbit translation elongation factor 1 alpha stimulates the activity of homologous aminoacyl-tRNA synthetase. -1996.- FEBS Lett. 382, 18-20.

Biological Sensors

1. Slinchenko O., Gorbach L., Matyushov V., Brovko O., Piletsky S., Sergeeva L., El’ska G., Sergeyeva T. Catalytic molecularly imprinted polymer membranes: Development of the biomimetic sensor for phenols detection. Anal. Chim. Acta. - 2010. - Vol. 659, N 1-2. - P. 274-279

2. Sergeyeva T., Gorbach L., Slinchenko O., Goncharova L., Piletska O., Brovko O., Sergeeva L., El’ska G. Towards development of colorimetric test-systems for phenols detection based on computationally-designed molecularly imprinted polymer membranes. Material Science and Engineering C. - 2010. - Vol. 30. - P. 431-436

3. Soldatkin O.O., Peshkova V., Dzyadevych S., Soldatkin O.P., Jaffrezic-Renault N. El’skaya A. Novel sucrose three-enzyme conductometric biosensor. Material Science and Engineering C.- 2008.- V.28.-P. 959-964

4. Sergeyeva T., Piletska O., Piletsky S., Sergeeva L., Brovko O., El'ska G. Data on the structure and recognition properties of the template-selective binding sites in semi-IPN-based molecularly imprinted polymer membranes. Materials Science and Engineering: C. - 2008-. V. 28, - P. 1472-1479

5. Dzyadevych S., Arkhypova V., Soldatkin A., El’skaya A., Martelet C., Jaffrezic-Renault N. Amperometric enzyme biosensors: past, present and future. ITBM-RBM.- 2008.- V.29.-P. 171-180.

6. Dzyadevych S., Arkhypova V., Soldatkin A., El’skaya A., Martelet C., Jaffrezic-Renault N. Conductometric enzyme biosensors. Handbook of Biosensors and Biochips / Eds R. S.Marks, C.R.Lowe, D.C.Culen, H.H.Weetall, I.Karube.- Wiley-Interscience.- 2007.- P. 379-394.

7. Dzyadevych S., Soldatkin A., El’skaya A., Martelet C., Jaffrezic-Renault N. Enzyme biosensors based on ion-selective field-effect transistors. Analytica Chimica Acta.- 2006, 568.- P.248-258.

8. Soldatkin A., Dzyadevych S., El’skaya A., Martelet C., Jaffrezic-Renault N. Pathways for improving potentiometric and conductometric enzymatic biosensors. In: Encyclopedia of Sensors (Eds. C.A.Grimes, E.C.Dickey, M.V.Pishko).- California, USA: American Scientific Publishers.- 2006.- V.7.- P. 331-348.

9. Dzyadevych S., Soldatkin A., Arkhypova V., Martelet C., Jaffrezic-Renault N., El’skaya A. Electrochemical enzyme biosensors. Kyiv: IMBG.- 2006.- 72 p.

10. Soldatkin A., Dzyadevych S., El’skaya A., Martelet C., Jaffrezic-Renault N. Pathways for improving potentiometric and conductometric enzymatic biosensors. In: Encyclopedia of Sensors. - California, USA: American Scientific Publishers.- 2006.- V.7.- P. 331-348.

11. Soldatkin A., Arkhypova V., Dzyadevych S., El’skaya A., Gravoueille J.-M., Jaffrezic-Renault N., Martelet C. Analysis of the potato glycoalkaloids by using of enzyme biosensor based on pH-ISFETs, Talanta. - 2005. -66. -P.28-33.

12. Dzyadevych S., Soldatkin A., Arkhypova V., El’skaya A., Chovelon J.-M., Georgiou C., Martelet C., Jaffrezic-Renault N. Early-warning electrochemical biosensor system for the environmental monitoring based on enzyme inhibition effect. Sensors and Actuators B: Chemical. 2005- V.-105.- P. 81-87

13. Arkhypova V., Dzyadevych S., Soldatkin A., Korpan Y., El’skaya A., Gravoueille J.-M., Martelet C., Jaffrezic-Renault N. Application of enzyme field effect transistors for fast detection of total glycoalkaloids content in potatoes, Sensors and Actuators B.- 2004.- 103.- P. 416-422.

14. Dzyadevych S., Arkhypova V., Martelet C., Jaffrezic-Renault N., Chovelon J.-M., El’skaya A., Soldatkin A. Potentiometric biosensors based on ISFETs and immobilized cholinesterases. Electroanalysis. - 2004. - 16. - P. 1873-1882.

15. Biloivan O., Dzyadevych S., Boubryak O., Soldatkin A., El’skaya A. Development of enzyme biosensor based on ISFETs for quantitative analysis of serine proteinases, Electroanalysis.- 2004.- 16.- P. 1883-1889.

16. Korpan Y., Nazarenko E., Skryshevskaya I., Martelet C., Jaffrezic-Renault N., El'skaya A. Potato Glycoalkaloids: True Safety or False Sense of Security?, Trends in Biotechnology.- 2004. -22, N3. -P.147-151.

17. Dzyadevych S., Arkhypova V., Soldatkin A., El’skaya A., Martelet C., Jaffrezic-Renault N. Enzyme biosensor for tomatine detection in tomatoes, Analytical Letters.- 2004. - 37, No 8.- P. 1611-1624.

18. Sergeyeva T., Piletsky S., Piletska E., Brovko O., Karabanova L., Sergeeva L., El’skaya A., Turner A. In situ formation of porous molecularly imprinted polymer membranes, Macromolecules.-2003.- 36.- N19. -P. 7352-7357.

19. Arkhypova V., Dzyadevych S., Soldatkin A., El’skaya A., Martelet C., Jaffrezic-Renault N. Development and optimisation of biosensors based on pH-sensitive field effect transistor and cholinesterase for sensitive detection of solanaceous glycoalkaloids, Biosensors & Bioelectronics.- 2003.- 18.- P. 1047-1053.

20. Dzyadevych S., Soldatkin A., Korpan Y., Arkhypova V., El’skaya A., Chovelon J.-M., Martelet C., Jaffrezic-Renault N. Biosensors based on enzyme field effect transistors for determination of some substrates and inhibitors, Analytical and Bioanalytical Chemistry.- 2003.- 377.- P. 496-506.

21. Sergeyeva T., Piletsky S., Brovko A., El'skaya A., Warner P., Turner A. Substance-selective polymer membranes, UK Patent Application, 0216333.5, 01.07.2002.

22. Sergeyeva T., S.A. Piletsky, E.V. Piletska, Brovko O., L.V. Karabanova, L.M. Sergeeva, A.P.F. Turner, A.V. El'skaya, In situ formation of porous molecularly imprinted polymer membranes. Macromolecules. - Vol. 36, no. 19, - P. 7352-7357, 2003.

23. Sergeyeva T., Piletsky S., Piletska E., Brovko O., Karabanova L., Sergeeva L., El’skaya A., Synthesis of molecularly imprinted polymer membranes for solid-phase extraction of triazine herbicides from aqueous solutions and their investigation // Reports of National Academy of Sciences of Ukraine. #. 6.- P. 170-174, 2003.

24. Dzyadevych S., Soldatkin A., Korpan Y., Arkhypova V., El’skaya A., Chovelon J.-M., Martelet C., Jaffrezic-Renault N. Biosensors based on enzyme field effect transistors for determination of some substrates and inhibitors. Analytical and Bioanalytical Chemistry.- 2003.- 377.- P. 496-506.

25. Arkhypova V., Dzyadevych S., Soldatkin A., El’skaya A., Martelet C., Jaffrezic-Renault N. Development and optimisation of biosensors based on pH-sensitive field effect transistor and cholinesterase for sensitive detection of solanaceous glycoalkaloids. Biosensors & Bioelectronics.- 2003.- 18.- P. 1047-1053.

26. Dzyadevych S., Arkhypova V., El'skaya A., Jaffrezic-Renault N., Martelet C., Soldatkin A. Conductometric enzyme biosensors for substrates or inhibitors analysis. Current Topics in Analytical Chemistry, 2001, 2, P. 179-186.