Триндяк Володимир Посада: Співробітник відділення біохімічної токсикології у Національному центрі токсикологічних досліджень. Адреса: 3900 NCTR Rd, HFT-140, Jefferson, AR 72079 USA Телефон: 011-870-543-7545 Факс: 011-870-543-7610 Е-мейл: volodymyr.tryndyak<AT>fda.hhs.gov

Наукові інтереси:

• Генетика та епігенетика раку
  
• Множинна медикаментозна стійкість під час раку

Нагороди:

2001-2003 Персональна Президентська стипендія для молодих науковців, Київ, Україна
2004- досі Стипендія на післядипломне стажування, Інститут науки та освіти в Оак Ріджі, штат Теннесі, СЩА


Членство у наукових об'єднаннях:

Європейська асоціація з дослідження раку (2003)
Американська асоціація з дослідження раку (2005)
Токсикологічне товариство (2007)


Вибрані публікації: (з 39 реферованих статтей)

1. Kovalchuk O., Filkowski J., Meservy J., Ilnytsky Y., Tryndyak V.P., Chekhun V.F., Pogribny I.P. Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Mol. Cancer Therapeutics, 2008, (in press).
2. Bagnyukova T.V., Tryndyak V.P., Montgomery B., Churchwell M.I., Karpf A.R., James S.R., Muskhelishvili L., Beland F.A., Pogribny I.P. Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene. Carcinogenesis. 2008; Jan 19 (in press).
3. Kovalchuk O., Tryndyak V.P., Montgomery B., Boyko A., Kutanzi K., Zemp F., Warbitton A.R., Lafendresse J.R., Kovalchuk I., Beland F.A., Pogribny I.P. Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications, and aberrant microRNA expression. Cell Cycle. 2007; 6(16): 2010-2018.
4. Pogribny I.P., Bagnyukova T.V., Tryndyak V.P., Muskhelishvili L., Rodriguez-Juarez R., Kovalchuk O., Han T., Fuscoe J.C., Ross S.A., Beland F.A. Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis. Toxicology and Applied Pharmacology. 2007; 225(1): 61-9.
5. Pogribny I.P., Tryndyak V.P., Woods C.G., Witt S.E., Rusyn I. Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha. Mutation Research. 2007; 625(1-2): 62-71.
6. Koturbash I., Boyko A., Rodriguez-Juarez R., McDonald R., Tryndyak V., Kovalchuk I., Pogribny I., Kovalchuk O. Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo. Carcinogenesis. 2007; 28(8): 1831-1838.
7. Pogribny I.P., Tryndyak V.P., Boyko A., Rodriguez-Juarez R., Beland F.A., Kovalchuk O. Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure. Mutation Research. 2007; 619: 30-37.
8. Chekhun V.F., Lukyanova N.Yu., Kovalchuk O., Tryndyak V.P., Pogribny I.P. Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets. Mol. Cancer Ther. 2007; 6(3): 1089-98.
9. Tryndyak V.P., Kovalchuk O., Muskhelishvili L., Montgomery B., Rodriguez-Juarez R., Melnyk S., Ross S.A., Beland F.A., Pogribny I.P. Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis. Mol. Carcinogenesis. 2007; 46(3): 187-97.
10. Pogribny I.P., Tryndyak V.P., Muskhelishvili L., Rusyn I., Ross S.A. Methyl deficiency, alterations in global histones modifications and carcinogenesis. The J. of Nutrition. 2007; 137(1): 216S-22S.
11. Tryndyak V.P., Kovalchuk O., Pogribny I.P. Identification of differentially methylated sites within unmethylated DNA domains in normal and cancer cells. Analyt. Biochem. 2006; 356(2): 202-207.
12. Chekhun V.F., Mikhailenko V.M., Tryndyak V.P., Turov V.V., Chekhun S.V., Chaly O.V. NMR spectroscopy as a method of evaluation of the biological membrane sensitivity to cytostatics. Reports of the NAS of Ukraine. 2006; 10: 180-187.
13. Tryndyak V.P., Muskhelishvili L., Kovalchuk O., Rodriguez-Juarez R., Montgomery B., Churchwell M.I., Ross S.A., Beland F.A., Pogribny I.P. Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis. Carcinogenesis. 2006; 27(8): 1713-1720.
14. Pogribny I.P., Ross S.A., Tryndyak V.P., Pogribna M., Poirier L.A., Karpinets T.V. Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. Carcinogenesis. 2006; 27(6): 1180-1186.
15. Tryndyak V., Kovalchuk O., Pogribny I. Loss of DNA Methylation and Histone H4 Lysine 20 Trimethylation in Human Breast Cancer Cells is Associated with Aberrant Expression of DNA Methyltransferase 1, Suv4-20h2 Histone Methyltransferase and Methyl-Binding Proteins. Cancer Biol. Ther. 2006; 5(1): 65-70.
    
16. Pogribny I.P., Ross S.A., Wise C., Pogribna M., Jones E.A., Tryndyak V.P., James S.J., Dragan Y.P., Poirier L.A. Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency. Mutation Research. 2006; 593(1-2): 80-87.
17. Chekhun V.F., Kulik G.I., Yurchenko O.V., Tryndyak V.P., Todor I.N., Luniv L.S., Tregubova N.A., Pryzimirska T.V., Montgomery B., Rusetskaya N.V., Pogribny I.P. Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells. Cancer Letters. 2006; 231(1): 87-93.
18. Pogribny I., Koturbash I., Tryndyak V., Hudson D., Stevenson S.M.L., Sedelnikova O., Bonner W., Kovalchuk O. Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus. Mol. Cancer Res. 2005; 3(10): 553-561.