Русин Іван Посада: M.D., Ph.D., Професор відділу екологічних наук та інженерії Університету Північної Кароліни. Адреса: 0031 MHRC, CB#7431, Chapel Hill, NC, 27599, USA Телефон: 8-10-1-919-843-2596 Домашня сторінка: http://www.sph.unc.edu/?option=com_profiles&profileAction=ProfDetail&pid=702665970 Е-мейл: iir<AT>unc.edu

1994 Доктор медицини, Національний медичний університет імені О.О.Богомольця, Kиїв, Україна (з відзнакою).
2000 Ph.D. (Токсикологія), University of North Carolina at Chapel Hill.

Наукові інтереси:

• Токсикологія
• Вплив навколишнього середовища на здоров'я
  

Членство у наукових об'єднаннях:

Токсикологічне Товариство

Вибрані публікації (з 92 публікацій):

1. Pogribny, I.P., Rusyn, I. and Beland, F.A. Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: Studies in rodents. Environ Mol Mutagen In press.

2. Rusyn, I., Fry, R.C., Begley, T.J., Klapacz, J., Svensson, J.P., Ambrose, M., and Samson, L.D. Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates. PLoS ONE 2:e1252, 2007.

3. Pogribny, I.P., Tryndyak, V.P., Woods, C.G., Witt, S.E., and Rusyn, I. Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor α. Mutat Res 625:62-71, 2007.

4. Woods, C.G., Kosyk, O., Bradford, B.U., Ross, P.K., Burns, A.M., Cunningham, M.L., Qu, P., Ibrahim, J.G. and Rusyn I. Gene expression in mouse liver reveals a temporal shift in molecular pathways that mediate effects of peroxisome proliferators. Toxicol Appl Pharmacol 225:267-277, 2007.

5. Peffer, R., Moggs, J.G., Pastoor, T., Currie, R.A., Wright, J., Millburn, G., Waechter, F., and Rusyn, I. Mouse liver effects of Cyproconazole, a triazole fungicide: Role of the constitutive androstane receptor. Toxicol Sci 99:315-325, 2007.

6. Beyer, R., et al. Multi-center study of acetaminophen hepatotoxicity reveals the critical importance of biological endpoints in genomic analyses. Toxicol Sci 99:326-337, 2007.

7. Roberts, A., McMillan, L., Wang, W., Parker, J., Rusyn, I., and Threadgill, D. Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows. Bioinformatics 23:i401-i407, 2007.

8. Gatti, D., Maki, A., Chesler, E.J., Kirova, R., Lu, L., Wang, J., Williams, R.W., Perkins, A., Langston, M.A., Threadgill, D.W., and Rusyn, I. Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology 46:548-557, 2007.

9. Woods, C.G., Burns, A.M., Bradford, B.U., Ross, P.K., Kosyk, O., Swenberg, J.A., Cunningham, M.L., and Rusyn I. WY-14,643-induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase. Toxicol Sci 98:366-74, 2007.

10. Woods, C.G., Vanden Heuvel, J.P., and Rusyn, I. Genomic profiling in nuclear receptor-mediated toxicity. Toxicol Pathol 35:474-494, 2007.

11. Hammond, L.E., Albright, C.D., He, L., Rusyn, I., Watkins, S.M., Doughman, S.D., Lemasters, J.J., and Coleman, R.A. Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice. Exp Mol Pathol 82:210-219, 2007.

12. Maki, A., Kono, H., Gupta, M., Asakawa, M., Suzuki, T., Matsuda, M., Fujii, H., and Rusyn, I. Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma. Ann Surg Oncol 14:1182-90, 2007.

13. Roberts, R.A., Ganey, P.E., Ju, C., Kamendulis, L.M., Rusyn, I., and Klaunig, J.E. Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicol Sci 96:2-15, 2007.

14. Woods, C.G., Burns, A.M., Maki, A., Bradford, B.U., Cunningham, M.L., Connor, H.D., Kadiiska, M., Mason, R.P., Peters, J.M., and Rusyn, I. Sustained formation of α-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-α, but not NADPH oxidase. Free Radic Biol Med 42:335-342, 2007.

15. Pogribny, I.P., Tryndyak, V.P., Muskhelishvili, L., Rusyn, I., and Ross, S.A. Methyl deficiency, alterations in global histone modifications and carcinogenesis. J Nutr 137:216S-222S, 2007.

16. Yamashina S, Ikejima K, Rusyn I, Sato N. Glycine as a potent anti-angiogenic nutrient for tumor growth. J Gastroenterol Hepatol. 22:S62-64, 2007.