Кулік Георгій Посада: Асоційований професор, факультет біології раку, підрозділ наук про здоров'я університету Уейк Форест Адреса: Wake Forest University Health Sciences, Medical Center Boulevard, NRC 442 Winston-Salem, NC 27157 Телефон: (336)713-7650 Факс: (336)716-7661 Домашня сторінка: http://www.wfubmc.edu/Faculty/Kulik-George.htm Е-мейл: gkulik<AT>wfubmc.edu

1986 Факультет ветеринарної медицини, Українська сільськогосподарська академія, Київ.
1991 К.б.н (біологія), Інститут експериментальної патології, Київ, Україна.

Наукові інтереси:

• Анти-апоптозна сигнальна мережа
• BAD як мішень терапії
• Використання оптичних зображень для спостереження за сигнальними шляхами
• Направлена терапія що пригнічує анти-апоптозні сигнальні шляхи в моделях раку простати    
• Роль емоційного стресу у розвитку раку простати

Вибрані публікації:

Ivashchenko, Y., Goot, I., Garmanchuk, L., Kulik, G., Bykores, A. (1989). Changes in the number of epidermal growth factor receptors in hepatocytes during rat liver regeneration. Cytologia 11.

Ivashchenko, Y., Garmanchuk, L., Kulik, G. (1989). EGF-binding proteins in platelets and rat blood serum. Reports of Acad. Sci. Ukrainian SSR B3: 67-71.

Ivashchenko, Y., Garmanchuk, L., Philchenkov, A., Kulik, G., Kononenko, L., Bykores, A. (1990). Changes in the amount of epidermal growth factor and EGF-like polypeptides in the liver tissue of rats with hepatocarcinogenesis induced by N-diethylnitrosamine. Experimental Oncology 12: 31.

Kulik, G., Ivashchenko, Y., Kononenko, L., Bykores, A. (1991). Influence of epidermal growth factor on the protein phosphorylation in normal and transformed hepatocytes. Ukrainian Biochemical J. 63: 16.

Kulik, G., (1991). Cytotoxic effect of anti-epidermal growth factor receptor antibodies on A-431 cells and primary culture of normal and transformed hepatocytes. Experimental Oncology 13: 34-41.

Ivashchenko, Y., Kononenko, L., Philchenkov, A., Bykores, A., Philchenkov, A., Kulik, G. (1991). Purification of epidermal growth factor by hydrophobic chromatography. Experimental Oncology 13: 71-74.

Ivashchenko, Y., Kulik, G., Philchenkov, A. (1991). Relationship between oligomerization state of epidermal growth factor receptor, its affinity and activation. Bull. Exp. Biol. Med.: 84-87.

Philchenkov, A., Slukvin, I., Kudryavets, Y., Didkovskaya, L., Kulik, G., Chernishov, V., Bykores, A. Expression and functional activity of transferring receptor in human tumor cells of different histogenesis. (1992). Experimental Oncology 14: 22-27.

Kulik, G., Kononenko, L., Pogrebnoy, P., Bykores, A. (1992). Effect of 12-o-tetradecanoylphorbol-13-acetate an adenosine-3’-phosphate on dimerization of the epidermal growth factor receptors and association of dimers with cytoskeleton of A-431 cells. Experimental Oncology 14: 27-32.

Philchenkov, A., Slukvin, I., Pogrebnoy, P., Kudryavets, Y., Didkovskaya, L., Kulik, G., Chernishov, V., Bykores, A. (1992). Application of flow cytometry with anti-EGF-receptor antibody and 125I-EGF binding assay in human tumor cell lines. Experimental Oncology 14: 45-49.

Bozhok O., Bezdrobnyi Iu., Kulik G., Serkiz Ia., Kartel A. (1994). Protein phosphorylation and activity of insulin and epidermal growth factor receptors in liver plasma membranes of rats kept in the zone of the accident at the Chernobyl nuclear power station. Ukrainian Biochemical J. 66: 35-39.

Kulik, G., Kartel, A., Tarnavsky, D., Pogrebnoy, P., Bykores, A. (1994). TGF-a and EGF induce oligomerization of EGFR but differ in their ability to activate intrinsic tyrosine kinase. Experimental Oncology 16: 31-36.

Phylchenkov AA, Kulik GA (1995). Clonal variations of EGF receptor expression in spontaneously transformed murine embryo fibroblasts. Experimental Oncology 17: 243.

John E.Peterson, George Kulik, Tomas Jelinek, Christoph W. M. Reuter, John A. Shannon, and Michael J. Weber. (1996) Src phosphorylates the Insulin-like growth factor receptor on the autophosphorylation sites. The Journal of Biological Chemistry 271: 31562-31571.

George Kulik, Anke Klippel, and Michael J. Weber. (1997) Antiapoptotic signalling by the Insulin-like growth factor receptor, Phosphatidylinositol 3-kinase, and Akt. Molecular and Cellular Biology, 17: 1595-1606.

George Kulik and Michael J. Weber. (1998) Akt-dependent and independent survival signalling pathways utilized by IGF-I. Molecular and Cellular Biology, 18:6711-6718.

Jonatan P. Carson, George Kulik and Michael J. Weber. (1999) Anti-apoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of PI3 kinase and Akt/PKB. Cancer Res. 59: 1449-1453.

George Kulik, Jonathan P. Carson, Tomas Vomastek, Kevin Overman, Barry D. Gooch, Srinivasa Srinivasula, Emad Alnemri, Gabriel Nunez and Michael J. Weber. (2001) TNF-a induces BID cleavage and bypasses antiapoptotic signals in prostate cancer LNCaP cells. Cancer Res. 61: 2713-2719.

Jonathan P. Carson, Marcelina Behnam, Jennifer Sutton, Chunying Du, Xiaodong Wang, Donald Hunt, Michael J. Weber and George Kulik. (2002) Smac is required for cytochrome c-induced apoptosis in prostate cancer LNCaP cells. Cancer Res. 62: 18-23.

Konduru S. R. Sastry, Adrienne Joy Smith, Yelena Karpova, Sandeep Robert Datta, and George Kulik. (2006) Diverse anti-apoptotic signaling pathways activated by VIP, EGF and PI3K in prostate cancer cells converge on BAD. J Biol Chem. 281(30):20891-901.

Konduru S. R. Sastry, Yelena Karpova, and George Kulik. (2006) Epidermal Growth Factor Protects Prostate Cancer Cells from Apoptosis by Inducing BAD Phosphorylation via Redundant Signaling Pathways. J Biol. Chem. 281(37):27367-77.

Sastry KS, Karpova Y, Prokopovich S, Smith AJ, Essau B, Gersappe A, Carson JP, Weber MJ, Register TC, Chen YQ, Penn RB, Kulik G. (2007) Epinephrine protects cancer cells from apoptosis via activation of PKA and BAD phosphorylation. J Biol. Chem. May 11;282(19):14094-100.

Isabelle M. Berquin, Younong Min, Ruping Wu, Jiansheng Wu, Donna Perry, J. Mark Cline, Mike J. Thomas, Todd Thornburg, George Kulik, Iris J. Edwards, Ralph D’Agostino Jr., Adrienne Smith, Hao Zhang, Hong Wu, Jing X. Kang and Yong Q. Chen. (2007) Modulation of Prostate Cancer Genetic Risk by Omega-3 and Omega-6 Fatty Acids. J Clin Invest. 117(7):1866-1875.

Adrienne J. Smith, Yelena Karpova, Ralph D’Agostino Jr, Mark Willingham, and George Kulik (2009). Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS One. 2009 Jul 13;4(7):e622.